Matt Rowan

The Rowan Lab uses a combination of cutting-edge imaging, electrophysiological, optogenetic, and surgical techniques to answer fundamental questions about brain function. The research aims to uncover how the specialized properties of neurons allows for proper learning and behavior, with an emphasis on understanding how electrical and chemical signaling in the smallest regions of neurons (dendritic spines and axonal boutons) facilitate these processes. The Rowan Lab motivated to understand how these mechanisms are affected in the context of neurological disorders such as Alzheimer’s and Autism.

Batch processing of brain tissue sections for millimeter-scale serial section transmission electron microscopy connectomics

T. Lee, Batch processing of brain tissue sections for millimeter-scale serial section transmission electron microscopy connectomics, Doctoral Dissertation, Summer 2019

Capillary-Based and Stokes-Based Trapping of Serial Sections for Scalable 3D-EM Connectomics

Timothy J. Lee, Mighten C. Yip, Aditi Kumar, Colby F. Lewallen, Daniel J. Bumbarger, R. Clay Reid and Craig R. Forest, Capillary-Based and Stokes-Based Trapping of Serial Sections for Scalable 3D-EM Connectomics, eNeuro 24 February 2020, 7 (2) ENEURO.0328-19.2019; DOI: https://doi.org/10.1523/ENEURO.0328-19.2019

Large-scale neuroanatomy using LASSO: Loop-based Automated Serial Sectioning Operation

T.J. Lee, A. Kumar, A.H. Balwani, D. Brittain, S. Kinn, C.A. Tovey, E.L. Dyer, N.M. da Costa, R.C. Reid, C.R. Forest*, D.J. Bumbarger* (*co-corresponding authors). Large-scale neuroanatomy using LASSO: Loop-based Automated Serial Sectioning Operation, PLOS One 13(10): e0206172. https://doi.org/10.1371/journal.pone.0206172 (2018)

Transport and trapping of nanosheets via hydrodynamic forces and curvature-induced capillary quadrupolar interactions

T.J. Lee, C.F. Lewallen, D.J. Bumbarger, P.J. Yunker, R.C. Reid, C.R. Forest. Transport and trapping of nanosheets via hydrodynamic forces and curvature-induced capillary quadrupolar interactions, Journal of Colloid and Interface Science (2018). DOI: 10.1016/j.jcis.2018.07.068

Cell membrane tracking in living brain tissue using differential interference contrast microscopy

J. Lee, I. Kolb, C.R. Forest, C.J. Rozell, Cell membrane tracking in living brain tissue using differential interference contrast microscopy, IEEE Transactions on image processing, 2018 Apr; 27(4):1847-1861. doi: 10.1109/TIP.2017.2787625.

Noninvasive optical inhibition with a red-shifted microbial rhodopsin

A.S. Chuong, M.L. Miri, L.C. Acker, S.B. Kodandaramaiah, M.A. Henninger, M. Ogawa, R.C. Bandler, N.C. Klapoetke, X. Gu, B.D. Allen, C.R. Forest, B.Y. Chow, X. Han, J.A. Cardin, E.S. Boyden, Noninvasive optical inhibition with a red-shifted microbial rhodopsin, Nature Neuroscience. Vol 17, p. 1123-1129, July 2014.